Dracula, Mavis, Johnny and the rest of the Drac Pack take a vacation on a luxury Monster Cruise Ship, where Dracula falls in love with the ship's captain, Ericka, who's secretly a descendant of Abraham Van Helsing, the notorious monster slayer.
When Van Helsing's mysterious invention, the Monsterfication Ray, goes haywire, Drac and his monster pals are all transformed into humans, and Johnny becomes a monster. In their new mismatched bodies, Drac and Johnny must team up and race across the globe to find a cure before it's too late, and before they drive each other crazy.
When the old-old-old-fashioned vampire Vlad arrives at the hotel for an impromptu family get-together, Hotel Transylvania is in for a collision of supernatural old-school and modern day cool.
Dracula, who operates a high-end resort away from the human world, goes into overprotective mode when a boy discovers the resort and falls for the counts teen-aged daughter.
Mr. and Mrs. Twit are the meanest, smelliest, nastiest people in the world who also happen to own and operate the most disgusting, most dangerous, most idiotic amusement park in the world, Twitlandia. But when the Twits rise to power in their town, two brave orphans and a family of magical animals are forced to become as tricky as the Twits in order to save the city.