Phoebe Titus is a tough, swaggering pioneer woman, but her ways become decidedly more feminine when she falls for California bound Peter Muncie. But Peter won't be distracted from his journey and Phoebe is left alone and plenty busy with villains Jefferson Carteret and Lazarus Ward plotting at every turn to destroy her freighting company. She has not seen the last of Peter, however.
A simple stagecoach trip is complicated by the fact that Geronimo is on the warpath in the area. The passengers on the coach include a a drunken doctor, two women, a bank manager who has taken off with his client's money, and the famous Ringo Kid, among others.
Popular mailcoach driver Uncle Willie is in fact in league with the town's crooked banker. They plan to have the bank robbed after emptying it, and when Willie's choice for this doesn't show in time, he gets some local boys to do it. When his man does turn up he decides to stick around, as he is pals with the sheriff and also takes a shine to Willie's daughter Allison. This gives the bad men several new problems.
The arrival of the telegraph put Pony Express riders like John Blair and his pal Smoky out of work. A race will decide whether they or stageline owner Drake get the government mail contract.
John Wyatt is a government agent sent to smash a counterfeiting operation near the Mexican border. Joining Doc Carter's medicine show they arrive in the town where Curly Joe, who once framed Carter, resides.
When John Mason's father is killed, John is wounded. Attracted to his nurse Alice, a conflict arises between him and his friend Ben who plans to marry Alice. John later finds the killer of his father but goes to face him not knowing Ben has removed the bullets from his gun.
The Cattlemen's Association has called in the Mesquiteers to find cattle rustlers. They get Tex Riley to pose as Stony so Stony can arrive posing as a wanted outlaw. This gets Stony into the gang of rustlers and he alerts Tucson and Lullaby as to the next raid. But Hartley is on hand and unknown to anyone is the rustler's boss and he joins the posse with a plan that will do away with the Mesquiteers.
Elliott is hunted by Curtis who has spent six years behind bars because of his testimony. After knocking out several baddies and putting up with the zany antics of his sidekick Taylor, Elliott guns down his antagonist, but Luana Walters, the girl he almost marries, will not abide a gunslinger so Elliott is compelled to ride off alone into the sunset once more.
In 1889 pioneers race ahead of the law to claim free land in Oklahoma, forming wide-open towns. In one such, citizens elect Milt Dawson to challenge the self-appointed rule of gambler Ace Holmes, only to have him shot in the back. But leading the next batch of settlers is Milt's quick-on-the-draw son John, who gets help from friendly outlaws.
Though he fought for the North in the Civil War, John is asked by the Governor of Texas to get rid of some troublesome carpetbaggers. He enlists the help of Holden before learning that Holden too is plundering the local folk.